J-147 has shown benefits in preclinical studies, including reversing cognitive deficits in animal models of Alzheimer's disease and aging, alleviating the pain of diabetic neuropathy, and exhibiting antidepressant-like and anxiolytic-like effects. It works by promoting neurotrophic factors like BDNF and NGF, and by protecting mitochondrial function. Additional potential benefits include improved outcomes in ischemic stroke and anti-aging effects like reduced blood vessel leakage and improved energy metabolism.
Neuroprotective and cognitive benefits
- Reverses cognitive deficits: J147 can improve memory and cognition in animal models of aging and Alzheimer's disease.
- Increases neurotrophic factors: It increases the expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which are important for learning, memory, and brain repair.
- Protects neurons: It shows neuroprotective effects in cell cultures and reduces markers for oxidative stress and inflammation.
- Reduces Alzheimer's markers: It has been shown to reduce soluble amyloid-beta (Aβ) levels and decrease markers of inflammation in animal models.
Other potential benefits
- Diabetic neuropathy: It alleviates painful symptoms in animal models of diabetic neuropathy.
- Antidepressant and anxiolytic effects: J147 has demonstrated antidepressant and anxiety-reducing activities in animal models.
- Ischemic stroke: It may improve the outcome of ischemic stroke and enhance treatment with tissue plasminogen activator (tPA).
- Anti-aging effects: It shows anti-aging effects in animal models, such as preventing blood vessel leakage in the brain and improving energy metabolism in cells.
Mechanism of action
- Mitochondrial function: J147 targets a protein in mitochondria (ATP synthase), which helps maintain cellular energy production and protects against cell death.
- Metabolic effects: It can decrease blood plasma free fatty acid levels by activating a pathway in the liver that supports energy production.