SLU-PP-332 is an experimental compound, often referred to as an “exercise mimetic,” that is being researched for its ability to replicate many of the metabolic benefits of physical activity by activating estrogen-related receptors (ERRs) in the body. Its potential benefits, primarily observed in preclinical animal studies, include:
Metabolic and Weight Management
- Fat Loss: Studies in obese mice showed the compound significantly reduced fat mass (up to 12% of body weight) without changes in food intake or exercise levels, by promoting the use of fat for energy (fatty acid oxidation).
- Improved Metabolic Health: It enhanced overall metabolism and improved markers associated with metabolic syndrome, such as reducing fasting glucose, insulin levels, and cholesterol/triglyceride levels in mouse models.
- Insulin Sensitivity: The compound has shown potential to improve insulin sensitivity, which is a key factor in managing or preventing type 2 diabetes.
- Fatty Liver (NAFLD/NASH): Early research suggests it can reverse hepatic steatosis (fatty liver disease) by reducing fat accumulation in the liver.
Physical Performance and Longevity
- Enhanced Endurance: In studies, mice treated with SLU-PP-332 could run significantly longer and farther, demonstrating a boost in exercise capacity.
- Muscle Function: It supports the development of fatigue-resistant muscle fibers and helps maintain muscle mass, potentially countering age-related muscle loss (sarcopenia).
- Mitochondrial Health: The peptide increases mitochondrial biogenesis (the creation of new cellular energy factories) and improves their function, a core aspect of healthy aging and increased energy production.
- Anti-Aging and Inflammation: It may suppress age-associated inflammatory markers and reduce oxidative stress, contributing to broader longevity and cellular repair benefits.
Potential Therapeutic Applications
- Cardioprotective Properties: The compound has shown promise in improving cardiac function, potentially offering a future therapeutic option for heart failure.
- Organ Protection: By improving metabolic health and reducing inflammation, it may offer indirect protective benefits for organs like the kidneys.
- Support for Immobile Individuals: One of its most promising uses is for individuals who are physically unable to exercise due to injury, disability, or chronic illness, allowing them to gain some of the health benefits of physical activity.
https://www.jrenendo.com/PDF/jre-10-e25143.pdf
https://www.peptidesciences.com/peptide-research/what-is-slu-pp-332-how-does-it-work
https://www.ahajournals.org/doi/10.1161/circ.144.suppl_1.9682
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